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MCC 555

CAS No. 161600-01-7

MCC 555( Isaglitazone | Netoglitazone | RWJ 241947 )

Catalog No. M12353 CAS No. 161600-01-7

MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    MCC 555
  • Note
    Research use only, not for human use.
  • Brief Description
    MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM.
  • Description
    MCC 555 (Isaglitazone;Netoglitazone;RWJ 241947) is an activating ligand of PPARγ with EC50 of 8 uM, exhibts greater antidiabetic potency that other TZDs including BRL49653; profoundly suppresses growth of PC-3 prostate cancer xenografts with prominent apoptosis, as well as fibrosis, including inflammatory and giant cell reaction in the remaining tumor tissue.Diabetes Phase 2 Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    Isaglitazone | Netoglitazone | RWJ 241947
  • Pathway
    Metabolic Enzyme/Protease
  • Target
    PPAR
  • Recptor
    PPAR
  • Research Area
    Metabolic Disease
  • Indication
    Diabetes

Chemical Information

  • CAS Number
    161600-01-7
  • Formula Weight
    381.421
  • Molecular Formula
    C21H16FNO3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (655.45 mM)
  • SMILES
    O=C(N1)SC(CC2=CC=C3C=C(OCC4=CC=CC=C4F)C=CC3=C2)C1=O
  • Chemical Name
    5-[[6-[(2-fluorophenyl)methoxy]-2-naphthalenyl]methyl]-2,4-thiazolidinedione

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reginato MJ, et al. J Biol Chem. 1998 Dec 4;273(49):32679-84. 2. Kumagai T, et al. Clin Cancer Res. 2004 Feb 15;10(4):1508-20. 3. Cekanova M, et al. Eur J Pharmacol. 2010 Jul 10;637(1-3):30-7.
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